Central Immune Senescence, Reversal Potentials

نویسندگان

  • Krisztian Kvell
  • Judit E. Pongracz
چکیده

A pioneer of ageing research, August Weismann has established two rather opposing concepts for aging and even today both gather numerous followers. One is the adaptive concept, according to which ageing has evolved to cleanse the population from old, nonreproductive consumers. The other, non-adaptive concept suggests that ageing is due to greater weight on early survival / reproduction rather than vigour at later ages. This latter has been reshaped by the theory of antagonistic pleiotropy (Ljubuncic et al. 2009).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Obtaining specimens with slowed, accelerated and reversed aging in the honey bee model.

Societies of highly social animals feature vast lifespan differences between closely related individuals. Among social insects, the honey bee is the best established model to study how plasticity in lifespan and aging is explained by social factors. The worker caste of honey bees includes nurse bees, which tend the brood, and forager bees, which collect nectar and pollen. Previous work has show...

متن کامل

Premature T Cell Senescence in Pediatric CKD.

An individual's immune function, susceptibility to infection, and response to immunosuppressive therapy are influenced in part by his/her T cell maturation state. Although childhood is the most dynamic period of immune maturation, scant information regarding the variability of T cell maturation in children with renal disease is available. In this study, we compared the T cell phenotype in child...

متن کامل

Character Association in Improved Mulberry Genotypes Exhibiting Delayed Leaf Senescence

Mulberry (Morus spp.) is a perennial tree cultivated for its foliage to rear the domesticated silkworm, Bombyx mori L. Mulberry has improved through conventional breeding in general aims to improve the quantity and quality of leaf yield, which have direct bearing on silk productivity. Leaf senescence is one of the major constraints, which restricts the quantity of quality leaf availability for ...

متن کامل

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

Oncogene-induced senescence can provide a protective mechanism against tumour progression. However, production of cytokines and growth factors by senescent cells may contribute to tumour development. Thus, it is unclear whether induction of senescence represents a viable therapeutic approach. Here, using a mouse model with orthotopic implantation of metastatic melanoma tumours taken from 19 pat...

متن کامل

Reversal of senescence by N resupply to N-starved Arabidopsis thaliana: transcriptomic and metabolomic consequences

Leaf senescence is a developmentally controlled process, which is additionally modulated by a number of adverse environmental conditions. Nitrogen shortage is a well-known trigger of precocious senescence in many plant species including crops, generally limiting biomass and seed yield. However, leaf senescence induced by nitrogen starvation may be reversed when nitrogen is resupplied at the ons...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012